Transcriptional repression by a secondary DNA binding surface of DNA topoisomerase I safeguards against hypertranscription

Abstract Regulation of global transcription output is important for normal development and disease, but little is known about the mechanisms Range Hood Ducting involved.DNA topoisomerase I (TOP1) is an enzyme well-known for its role in relieving DNA supercoils for enabling transcription.Here, we report a non-enzymatic function of TOP1 that downregu

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The remote allosteric control of Orai channel gating.

Calcium signals drive an endless array of cellular responses including secretion, contraction, transcription, cell division, and growth.The ubiquitously expressed Orai family of plasma membrane (PM) Biotin ion channels mediate Ca2+ entry signals triggered by the Ca2+ sensor Stromal Interaction Molecule (STIM) proteins of the endoplasmic reticulum (

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A Novel Interference Suppression Method for Interrupted Sampling Repeater Jamming Based on Singular Spectrum Entropy Function

As a new type of jamming, the interrupted sampling repeater jamming (ISRJ) derived from the digital radio frequency memory (DRFM) technology, can generate coherent multiple false targets after pulse compression.At present, the traditional interference suppression method and its improved methods have insufficient characteristics and poor detection p

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